Ontology highlight
ABSTRACT:
SUBMITTER: Palmer KL
PROVIDER: S-EPMC2168676 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Palmer Kelli L KL Aye Lindsay M LM Whiteley Marvin M
Journal of bacteriology 20070914 22
The sputum (mucus) layer of the cystic fibrosis (CF) lung is a complex substrate that provides Pseudomonas aeruginosa with carbon and energy to support high-density growth during chronic colonization. Unfortunately, the CF lung sputum layer has been difficult to mimic in animal models of CF disease, and mechanistic studies of P. aeruginosa physiology during growth in CF sputum are hampered by its complexity. In this study, we performed chromatographic and enzymatic analyses of CF sputum to devel ...[more]