Ontology highlight
ABSTRACT:
SUBMITTER: Uekita T
PROVIDER: S-EPMC2169043 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Uekita Takamasa T Jia Lin L Narisawa-Saito Mako M Yokota Jun J Kiyono Tohru T Sakai Ryuichi R
Molecular and cellular biology 20070904 21
Malignant tumor cells frequently achieve resistance to anoikis, a form of apoptosis induced by detachment from the basement membrane, which results in the anchorage-independent growth of these cells. Although the involvement of Src family kinases (SFKs) in this alteration has been reported, little is known about the signaling pathways involved in the regulation of anoikis under the control of SFKs. In this study, we identified a membrane protein, CUB-domain-containing protein 1 (CDCP1), as an SF ...[more]