Acetylated histone H3 and H4 mark the upregulated LMP2A promoter of Epstein-Barr virus in lymphoid cells.
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ABSTRACT:
SUBMITTER: Gerle B
PROVIDER: S-EPMC2169097 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Publications
Acetylated histone H3 and H4 mark the upregulated LMP2A promoter of Epstein-Barr virus in lymphoid cells.
Gerle Borbala B Koroknai Anita A Fejer György G Bakos Agnes A Banati Ferenc F Szenthe Kalman K Wolf Hans H Niller Hans Helmut HH Minarovits Janos J Salamon Daniel D
Journal of virology 20070926 23
We analyzed the levels of acetylated histones and histone H3 dimethylated on lysine 4 (H3K4me2) at the LMP2A promoter (LMP2Ap) of Epstein-Barr virus in well-characterized type I and type III lymphoid cell line pairs and additionally in the nasopharyngeal carcinoma cell line C666-1 by using chromatin immunoprecipitation. We found that enhanced levels of acetylated histones marked the upregulated LMP2Ap in lymphoid cells. In contrast, in C666-1 cells, the highly DNA-methylated, inactive LMP2Ap was ...[more]
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