Ontology highlight
ABSTRACT:
SUBMITTER: Haider Y
PROVIDER: S-EPMC2169220 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Haider Yussef Y Malizia Andrea P AP Keating Dominic T DT Birch Mary M Tomlinson Annette A Martin Gail G Ferguson Mark Wj MW Doran Peter P PP Egan Jim J JJ
Journal of inflammation (London, England) 20070920
<h4>Background</h4>Idiopathic Pulmonary Fibrosis (IPF) is a progressive diffuse disease involving the lung parenchyma. Despite recent advances, the molecular mechanisms of the initiation and progression of this disease remain elusive. Previous studies have demonstrated TGFbeta1 as a key effector cytokine in the development of lung fibrosis.<h4>Methods</h4>In this study we have used a transgenic mouse based strategy to identify the effect of overexpression of this key effector mediator on the dev ...[more]