Ontology highlight
ABSTRACT:
SUBMITTER: van Loo PF
PROVIDER: S-EPMC2169408 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
van Loo Pieter Fokko PF Mahtab Edris A F EA Wisse Lambertus J LJ Hou Jun J Grosveld Frank F Suske Guntram G Philipsen Sjaak S Gittenberger-de Groot Adriana C AC
Molecular and cellular biology 20071008 24
Mice lacking the zinc finger transcription factor specificity protein 3 (Sp3) die prenatally in the C57BL/6 background. To elucidate the cause of mortality we analyzed the potential role of Sp3 in embryonic heart development. Sp3 null hearts display defective looping at embryonic day 10.5 (E10.5), and at E14.5 the Sp3 null mutants have developed a range of severe cardiac malformations. In an attempt to position Sp3 in the cardiac developmental hierarchy, we analyzed the expression patterns of >1 ...[more]