Ontology highlight
ABSTRACT:
SUBMITTER: Padash Barmchi M
PROVIDER: S-EPMC2171764 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Padash Barmchi Mojgan M Rogers Stephen S Häcker Udo U
The Journal of cell biology 20050207 4
Morphogenesis of the Drosophila melanogaster embryo is associated with a dynamic reorganization of the actin cytoskeleton that is mediated by small GTPases of the Rho family. Often, Rho1 controls different aspects of cytoskeletal function in parallel, requiring a complex level of regulation. We show that the guanine triphosphate (GTP) exchange factor DRhoGEF2 is apically localized in epithelial cells throughout embryogenesis. We demonstrate that DRhoGEF2, which has previously been shown to regul ...[more]