Ontology highlight
ABSTRACT:
SUBMITTER: Kishi M
PROVIDER: S-EPMC2171857 | biostudies-literature | 2005 Apr
REPOSITORIES: biostudies-literature
Kishi Masashi M Kummer Terrance T TT Eglen Stephen J SJ Sanes Joshua R JR
The Journal of cell biology 20050401 2
In both neurons and muscle fibers, specific mRNAs are concentrated beneath and locally translated at synaptic sites. At the skeletal neuromuscular junction, all synaptic RNAs identified to date encode synaptic components. Using microarrays, we compared RNAs in synapse-rich and -free regions of muscles, thereby identifying transcripts that are enriched near synapses and that encode soluble membrane and nuclear proteins. One gene product, LL5beta, binds to both phosphoinositides and a cytoskeletal ...[more]