Ontology highlight
ABSTRACT:
SUBMITTER: MacDonald JI
PROVIDER: S-EPMC2172297 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
MacDonald James I S JI Kubu Chris J CJ Meakin Susan O SO
The Journal of cell biology 20040301 6
We provide the first characterization of a novel signaling adapter, Nesca, in neurotrophic signal transduction. Nesca contains a RUN domain, a WW domain, a leucine zipper, a carboxyl-terminal SH3 domain, and several proline-rich regions. Nesca is highly expressed in the brain, is serine phosphorylated, and mobilizes from the cytoplasm to the nuclear membrane in response to neurotrophin, but not epidermal growth factor, stimulation in a MEK-dependent process. Overexpression studies in PC12 cells ...[more]