Ontology highlight
ABSTRACT:
SUBMITTER: Gassmann R
PROVIDER: S-EPMC2172304 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Gassmann Reto R Carvalho Ana A Henzing Alexander J AJ Ruchaud Sandrine S Hudson Damien F DF Honda Reiko R Nigg Erich A EA Gerloff Dietlind L DL Earnshaw William C WC
The Journal of cell biology 20040712 2
The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Here, we describe Borealin, a novel member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin; and Borealin binds Survivin and INCENP in vitro. A second complex contains Aurora B and INCENP, but no Borealin or Survivin. Depletion of Borealin by RNA interference delays mitotic prog ...[more]