Ontology highlight
ABSTRACT:
SUBMITTER: Williams CC
PROVIDER: S-EPMC2172499 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Williams Christopher C CC Allison June G JG Vidal Gregory A GA Burow Matthew E ME Beckman Barbara S BS Marrero Luis L Jones Frank E FE
The Journal of cell biology 20041101 3
In the lactating breast, ERBB4 localizes to the nuclei of secretory epithelium while regulating activities of the signal transducer and activator of transcription (STAT) 5A transcription factor essential for milk-gene expression. We have identified an intrinsic ERBB4 NLS (residues 676-684) within the ERBB4 intracellular domain (4ICD) that is essential for nuclear accumulation of 4ICD. To determine the functional significance of 4ICD nuclear translocation in a physiologically relevant system, we ...[more]