Ontology highlight
ABSTRACT:
SUBMITTER: Innocenti M
PROVIDER: S-EPMC2172734 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
Innocenti Metello M Frittoli Emanuela E Ponzanelli Isabella I Falck John R JR Brachmann Saskia M SM Di Fiore Pier Paolo PP Scita Giorgio G
The Journal of cell biology 20030106 1
Class I phosphoinositide 3-kinases (PI3Ks) are implicated in many cellular responses controlled by receptor tyrosine kinases (RTKs), including actin cytoskeletal remodeling. Within this pathway, Rac is a key downstream target/effector of PI3K. However, how the signal is routed from PI3K to Rac is unclear. One possible candidate for this function is the Rac-activating complex Eps8-Abi1-Sos-1, which possesses Rac-specific guanine nucleotide exchange factor (GEF) activity. Here, we show that Abi1 ( ...[more]