Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.
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ABSTRACT:
SUBMITTER: Churin Y
PROVIDER: S-EPMC2172921 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Publications
Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.
Churin Yuri Y Al-Ghoul Laila L Kepp Oliver O Meyer Thomas F TF Birchmeier Walter W Naumann Michael M
The Journal of cell biology 20030401 2
Infection with the human microbial pathogen Helicobacter pylori is assumed to lead to invasive gastric cancer. We find that H. pylori activates the hepatocyte growth factor/scatter factor receptor c-Met, which is involved in invasive growth of tumor cells. The H. pylori effector protein CagA intracellularly targets the c-Met receptor and promotes cellular processes leading to a forceful motogenic response. CagA could represent a bacterial adaptor protein that associates with phospholipase Cgamma ...[more]
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