Ontology highlight
ABSTRACT:
SUBMITTER: Niethammer P
PROVIDER: S-EPMC2173281 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Niethammer Philipp P Delling Markus M Sytnyk Vladimir V Dityatev Alexander A Fukami Kiyoko K Schachner Melitta M
The Journal of cell biology 20020429 3
The neural cell adhesion molecule (NCAM) has been reported to stimulate neuritogenesis either via nonreceptor tyrosine kinases or fibroblast growth factor (FGF) receptor. Here we show that lipid raft association of NCAM is crucial for activation of the nonreceptor tyrosine kinase pathway and induction of neurite outgrowth. Transfection of hippocampal neurons of NCAM-deficient mice revealed that of the three major NCAM isoforms only NCAM140 can act as a homophilic receptor that induces neurite ou ...[more]