Ontology highlight
ABSTRACT:
SUBMITTER: Shinzawa K
PROVIDER: S-EPMC2173704 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Shinzawa Koei K Tsujimoto Yoshihide Y
The Journal of cell biology 20031215 6
Apoptosis is defined on the basis of morphological changes like nuclear fragmentation and chromatin condensation, which are dependent on caspases. Many forms of caspase-independent cell death have been reported, but the mechanisms are still poorly understood. We found that hypoxic cell death was independent of caspases and was associated with significant nuclear shrinkage. Neither Bcl-2 nor Apaf-1 deficiency prevented hypoxic nuclear shrinkage. To understand the molecular mechanism of the nuclea ...[more]