Ontology highlight
ABSTRACT:
SUBMITTER: Grevengoed EE
PROVIDER: S-EPMC2173720 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Grevengoed Elizabeth E EE Fox Donald T DT Gates Julie J Peifer Mark M
The Journal of cell biology 20031215 6
The proto-oncogenic kinase Abelson (Abl) regulates actin in response to cell signaling. Drosophila Abl is required in the nervous system, and also in epithelial cells, where it regulates adherens junction stability and actin organization. Abl acts at least in part via the actin regulator Enabled (Ena), but the mechanism by which Abl regulates Ena is unknown. We describe a novel role for Abl in early Drosophila development, where it regulates the site and type of actin structures produced. In Abl ...[more]