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Theory of passive permeability through lipid bilayers.

ABSTRACT: Recently measured water permeability through bilayers of different lipids is most strongly correlated with the area per lipid A rather than with other structural quantities such as the thickness. This paper presents a simple three-layer theory that incorporates the area dependence in a physically realistic way and also includes the thickness as a secondary modulating parameter. The theory also includes the well-known strong correlation of permeability upon the partition coefficients of general solutes in hydrocarbon environments (Overton's rule). Two mathematical treatments of the theory are given; one model uses discrete chemical kinetics and one model uses the Nernst-Planck continuum equation. The theory is fit to the recent experiments on water permeability in the accompanying paper.

SUBMITTER: Nagle JF

PROVIDER: S-EPMC2174158 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature

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Theory of passive permeability through lipid bilayers.

Nagle John F JF Mathai John C JC Zeidel Mark L ML Tristram-Nagle Stephanie S

The Journal of general physiology 20080101 1

Recently measured water permeability through bilayers of different lipids is most strongly correlated with the area per lipid A rather than with other structural quantities such as the thickness. This paper presents a simple three-layer theory that incorporates the area dependence in a physically realistic way and also includes the thickness as a secondary modulating parameter. The theory also includes the well-known strong correlation of permeability upon the partition coefficients of general s ...[more]

PMID: 18166627

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