Ontology highlight
ABSTRACT:
SUBMITTER: Krause M
PROVIDER: S-EPMC2175102 | biostudies-literature | 2000 Apr
REPOSITORIES: biostudies-literature
Krause M M Sechi A S AS Konradt M M Monner D D Gertler F B FB Wehland J J
The Journal of cell biology 20000401 1
T cell receptor (TCR)-driven activation of helper T cells induces a rapid polarization of their cytoskeleton towards bound antigen presenting cells (APCs). We have identified the Fyn- and SLP-76-associated protein Fyb/SLAP as a new ligand for Ena/ vasodilator-stimulated phosphoprotein (VASP) homology 1 (EVH1) domains. Upon TCR engagement, Fyb/SLAP localizes at the interface between T cells and anti-CD3-coated beads, where Evl, a member of the Ena/VASP family, Wiskott-Aldrich syndrome protein (WA ...[more]