Ontology highlight
ABSTRACT:
SUBMITTER: Charpentier E
PROVIDER: S-EPMC2175163 | biostudies-literature | 2000 Apr
REPOSITORIES: biostudies-literature
Charpentier E E Lavker R M RM Acquista E E Cowin P P
The Journal of cell biology 20000401 2
Plakoglobin regulates cell adhesion by providing a modulatable connection between both classical and desmosomal cadherins and their respective cytoskeletal linker proteins. Both plakoglobin and the related protein beta-catenin are posttranscriptionally upregulated in response to Wnt-1 in cultured cells. Upregulation of beta-catenin has been implicated in potentiating hyperproliferation and tumor formation. To investigate the role of plakoglobin in these functions we expressed a full-length (PG) ...[more]