Membrane topology of the Drosophila OR83b odorant receptor.
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ABSTRACT:
SUBMITTER: Lundin C
PROVIDER: S-EPMC2176074 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Publications
Membrane topology of the Drosophila OR83b odorant receptor.
Lundin Carolina C Käll Lukas L Kreher Scott A SA Kapp Katja K Sonnhammer Erik L EL Carlson John R JR Heijne Gunnar von Gv Nilsson IngMarie I
FEBS letters 20071120 29
By analogy to mammals, odorant receptors (ORs) in insects, such as Drosophila melanogaster, have long been thought to belong to the G-protein coupled receptor (GPCR) superfamily. However, recent work has cast doubt on this assumption and has tentatively suggested an inverted topology compared to the canonical N(out) - C(in) 7 transmembrane (TM) GPCR topology, at least for some Drosophila ORs. Here, we report a detailed topology mapping of the Drosophila OR83b receptor using engineered glycosylat ...[more]
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