Ontology highlight
ABSTRACT:
SUBMITTER: Dudman JT
PROVIDER: S-EPMC2179894 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Dudman Joshua T JT Tsay David D Siegelbaum Steven A SA
Neuron 20071201 5
Synaptic potentials originating at distal dendritic locations are severely attenuated when they reach the soma and, thus, are poor at driving somatic spikes. Nonetheless, distal inputs convey essential information, suggesting that such inputs may be important for compartmentalized dendritic signaling. Here we report a new plasticity rule in which stimulation of distal perforant path inputs to hippocampal CA1 pyramidal neurons induces long-term potentiation at the CA1 proximal Schaffer collateral ...[more]