Ontology highlight
ABSTRACT:
SUBMITTER: Reeder JC
PROVIDER: S-EPMC21841 | biostudies-literature | 1999 Apr
REPOSITORIES: biostudies-literature
Reeder J C JC Cowman A F AF Davern K M KM Beeson J G JG Thompson J K JK Rogerson S J SJ Brown G V GV
Proceedings of the National Academy of Sciences of the United States of America 19990401 9
Chondroitin sulfate A (CSA) is an important receptor for the sequestration of Plasmodium falciparum in the placenta, but the parasite ligand involved in adhesion has not previously been identified. Here we report the identification of a var gene transcribed in association with binding to CSA and present evidence that the P. falciparum erythrocyte membrane protein 1 product of the gene is the parasite ligand mediating CSA binding. Description of this gene and the implication of P. falciparum eryt ...[more]