Ontology highlight
ABSTRACT:
SUBMITTER: Frias-Staheli N
PROVIDER: S-EPMC2184509 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Frias-Staheli Natalia N Giannakopoulos Nadia V NV Kikkert Marjolein M Taylor Shannon L SL Bridgen Anne A Paragas Jason J Richt Juergen A JA Rowland Raymond R RR Schmaljohn Connie S CS Lenschow Deborah J DJ Snijder Eric J EJ García-Sastre Adolfo A Virgin Herbert Whiting HW
Cell host & microbe 20071201 6
Ubiquitin (Ub) and interferon-stimulated gene product 15 (ISG15) reversibly conjugate to proteins and mediate important innate antiviral responses. The ovarian tumor (OTU) domain represents a superfamily of predicted proteases found in eukaryotic, bacterial, and viral proteins, some of which have Ub-deconjugating activity. We show that the OTU domain-containing proteases from nairoviruses and arteriviruses, two unrelated groups of RNA viruses, hydrolyze Ub and ISG15 from cellular target proteins ...[more]