Ontology highlight
ABSTRACT:
SUBMITTER: Pekny M
PROVIDER: S-EPMC2185074 | biostudies-literature | 1999 May
REPOSITORIES: biostudies-literature
Pekny M M Johansson C B CB Eliasson C C Stakeberg J J Wallén A A Perlmann T T Lendahl U U Betsholtz C C Berthold C H CH Frisén J J
The Journal of cell biology 19990501 3
In response to injury of the central nervous system, astrocytes become reactive and express high levels of the intermediate filament (IF) proteins glial fibrillary acidic protein (GFAP), vimentin, and nestin. We have shown that astrocytes in mice deficient for both GFAP and vimentin (GFAP-/-vim-/-) cannot form IFs even when nestin is expressed and are thus devoid of IFs in their reactive state. Here, we have studied the reaction to injury in the central nervous system in GFAP-/-, vimentin-/-, or ...[more]