Ontology highlight
ABSTRACT:
SUBMITTER: Roberts DL
PROVIDER: S-EPMC2185525 | biostudies-literature | 2001 Apr
REPOSITORIES: biostudies-literature
Roberts D L DL Merrison W W MacFarlane M M Cohen G M GM
The Journal of cell biology 20010401 1
Smac/DIABLO, a recently identified inhibitor of apoptosis protein (IAP)-binding protein, is released from the mitochondria during apoptosis and reportedly potentiates apoptosis by relieving the inhibition of IAPs on caspases. We now describe the molecular characterization of Smac beta, an alternatively spliced form of Smac, which lacks the mitochondrial-targeting sequence found in Smac and has a cortical distribution in both human embryonic kidney 293 and breast epithelial tumor MCF-7 cells. Sma ...[more]