Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen.

ABSTRACT: How the innate immune system tailors specific responses to diverse microbial infections is not well understood. Cells use a limited number of host receptors and signaling pathways to both discriminate among extracellular and intracellular microbes, and also to generate responses commensurate to each threat. Here, we have addressed these questions by using DNA microarrays to monitor the macrophage transcriptional response to the intracellular bacterial pathogen Listeria monocytogenes. By utilizing combinations of host and bacterial mutants, we have defined the host transcriptional responses to vacuolar and cytosolic bacteria. These compartment-specific host responses induced significantly different sets of target genes, despite activating similar transcription factors. Vacuolar signaling wa

SUBMITTER: Leber JH 

PROVIDER: S-EPMC2186359 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature