Ontology highlight
ABSTRACT:
SUBMITTER: Law CL
PROVIDER: S-EPMC2193019 | biostudies-literature | 1999 Apr
REPOSITORIES: biostudies-literature
Law C L CL Ewings M K MK Chaudhary P M PM Solow S A SA Yun T J TJ Marshall A J AJ Hood L L Clark E A EA
The Journal of experimental medicine 19990401 8
Propagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. SH2 domain-containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its expression is required for normal T cell development. We report the cloning and characterization of a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL). Expression of GrpL is restrict ...[more]