MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4.
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ABSTRACT:
SUBMITTER: Shimazu R
PROVIDER: S-EPMC2193086 | biostudies-literature | 1999 Jun
REPOSITORIES: biostudies-literature
Publications
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4.
Shimazu R R Akashi S S Ogata H H Nagai Y Y Fukudome K K Miyake K K Kimoto M M
The Journal of experimental medicine 19990601 11
Toll-like receptor 4 (TLR4) is a mammalian homologue of Drosophila Toll, a leucine-rich repeat molecule that can trigger innate responses against pathogens. The TLR4 gene has recently been shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS). TLR4 may be a long-sought receptor for LPS. However, transfection of TLR4 does not confer LPS responsiveness on a recipient cell line, suggesting a requirement for an additional molecule. Here, w ...[more]
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