Ontology highlight
ABSTRACT:
SUBMITTER: Lekstrom-Himes JA
PROVIDER: S-EPMC2193089 | biostudies-literature | 1999 Jun
REPOSITORIES: biostudies-literature
Lekstrom-Himes J A JA Dorman S E SE Kopar P P Holland S M SM Gallin J I JI
The Journal of experimental medicine 19990601 11
Neutrophil-specific granule deficiency (SGD) is a rare disorder characterized by recurrent pyogenic infections, defective neutrophil chemotaxis and bactericidal activity, and lack of neutrophil secondary granule proteins. CCAAT/enhancer binding protein (C/EBP)epsilon, a member of the leucine zipper family of transcription factors, is expressed primarily in myeloid cells, and its knockout mouse model possesses distinctive defects, including a lack of neutrophil secondary granule proteins. Sequenc ...[more]