Ontology highlight
ABSTRACT:
SUBMITTER: Jaleco AC
PROVIDER: S-EPMC2193482 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20011001 7
Notch signaling is known to differentially affect the development of lymphoid B and T cell lineages, but it remains unclear whether such effects are specifically dependent on distinct Notch ligands. Using a cell coculture assay we observed that the Notch ligand Delta-1 completely inhibits the differentiation of human hematopoietic progenitors into the B cell lineage while promoting the emergence of cells with a phenotype of T cell/natural killer (NK) precursors. In contrast, Jagged-1 did not dis ...[more]