Biosynthesis of glycosylphosphatidylinositol is essential to the survival of the protozoan parasite Toxoplasma gondii.
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ABSTRACT:
SUBMITTER: Wichroski MJ
PROVIDER: S-EPMC219362 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
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Biosynthesis of glycosylphosphatidylinositol is essential to the survival of the protozoan parasite Toxoplasma gondii.
Wichroski Michael J MJ Ward Gary E GE
Eukaryotic cell 20031001 5
The PIGA gene from Toxoplasma gondii has been cloned and characterized. Like mammalian PIGA, the transmembrane and C-terminal domains are sufficient to direct localization to the parasite endoplasmic reticulum. A functional copy of PIGA is required for tachyzoite viability, demonstrating that glycosylphosphatidylinositol biosynthesis is an essential process in T. gondii. ...[more]
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