Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez T
PROVIDER: S-EPMC2193757 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Fernandez Tania T Amoroso Stephanie S Sharpe Shellyann S Jones Gary M GM Bliskovski Valery V Kovalchuk Alexander A Wakefield Lalage M LM Kim Seong-Jin SJ Potter Michael M Letterio John J JJ
The Journal of experimental medicine 20020501 10
Transforming growth factor (TGF)-beta is the prototype in a family of secreted proteins that act in autocrine and paracrine pathways to regulate cell development and function. Normal cells typically coexpress TGF-beta receptors and one or more isoforms of TGF-beta, thus the synthesis and secretion of TGF-beta as an inactive latent complex is considered an essential step in regula-ting the activity of this pathway. To determine whether intracellular activation of TGF-beta results in TGF-beta liga ...[more]