Ontology highlight
ABSTRACT:
SUBMITTER: Steiner H
PROVIDER: S-EPMC21938 | biostudies-literature | 1999 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 19990501 10
The basal ganglia, a brain structure critical for sensorimotor and motivational aspects of behavior, contain very high levels of CB1 cannabinoid receptors. These receptors are activated by endogenous lipophilic ligands, and they are thought to mediate behavioral effects of cannabinoid drugs. To evaluate the role of the endogenous cannabinoid system in the regulation of basal ganglia pathways, we have investigated the effects of targeted deletion of CB1 receptors on gene expression of various neu ...[more]