Ontology highlight
ABSTRACT:
SUBMITTER: Saraiva M
PROVIDER: S-EPMC2194064 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Saraiva Margarida M Smith Philip P Fallon Padraic G PG Alcami Antonio A
The Journal of experimental medicine 20020901 6
CD30 is up-regulated in several human diseases and viral infections but its role in immune regulation is poorly understood. Here, we report the expression of a functional soluble CD30 homologue, viral CD30 (vCD30), encoded by ectromelia (mousepox) virus, a poxvirus that causes a severe disease related to human smallpox. We show that vCD30 is a 12-kD secreted protein that not only binds CD30L with high affinity and prevents its interaction with CD30, but it also induces reverse signaling in cells ...[more]