Complement protein C1q inhibits antibody-dependent enhancement of flavivirus infection in an IgG subclass-specific manner.
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ABSTRACT:
SUBMITTER: Mehlhop E
PROVIDER: S-EPMC2194657 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
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Complement protein C1q inhibits antibody-dependent enhancement of flavivirus infection in an IgG subclass-specific manner.
Mehlhop Erin E Ansarah-Sobrinho Camilo C Johnson Syd S Engle Michael M Fremont Daved H DH Pierson Theodore C TC Diamond Michael S MS
Cell host & microbe 20071201 6
Severe dengue virus infection can occur in humans with pre-existing antibodies against the virus. This observation led to the hypothesis that a subneutralizing antibody level in vivo can increase viral burden and cause more severe disease. Indeed, antibody-dependent enhancement of infection (ADE) in vitro has been described for multiple viruses, including the flaviviruses dengue virus and West Nile virus. Here, we demonstrate that the complement component C1q restricts ADE by anti-flavivirus IgG ...[more]
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