Ontology highlight
ABSTRACT:
SUBMITTER: Brayton KA
PROVIDER: S-EPMC219554 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Brayton Kelly A KA Meeus Patrick F M PF Barbet Anthony F AF Palmer Guy H GH
Infection and immunity 20031101 11
Vector-borne bacterial pathogens persist in the mammalian host by varying surface antigens to evade the existing immune response. To test whether the model of surface coat switching and immune evasion can be extended to a vector-borne bacterial pathogen with multiple immunodominant surface proteins, we examined Anaplasma marginale, a rickettsia with two highly immunogenic outer membrane proteins, major surface protein 2 (MSP2) and MSP3. The simultaneous clearance of variants of the two most immu ...[more]