Ontology highlight
ABSTRACT:
SUBMITTER: Alderson MR
PROVIDER: S-EPMC2195809 | biostudies-literature | 2000 Feb
REPOSITORIES: biostudies-literature
Alderson M R MR Bement T T Day C H CH Zhu L L Molesh D D Skeiky Y A YA Coler R R Lewinsohn D M DM Reed S G SG Dillon D C DC
The Journal of experimental medicine 20000201 3
Development of a subunit vaccine for Mycobacterium tuberculosis (Mtb) is likely to be dependent on the identification of T cell antigens that induce strong proliferation and interferon gamma production from healthy purified protein derivative (PPD)(+) donors. We have developed a sensitive and rapid technique for screening an Mtb genomic library expressed in Escherichia coli using Mtb-specific CD4(+) T cells. Using this technique, we identified a family of highly related Mtb antigens. The gene of ...[more]