Ontology highlight
ABSTRACT:
SUBMITTER: Hontz JS
PROVIDER: S-EPMC2197165 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Hontz Jill S JS Villar-Lecumberri Maria T MT Dreyfus Lawrence A LA Yoder Marilyn D MD
Acta crystallographica. Section F, Structural biology and crystallization communications 20060210 Pt 3
Cytolethal distending toxin (CDT) is a secreted protein toxin produced by several bacterial pathogens. The biologically active CDT subunit CdtB is an active homolog of mammalian type I DNase. Internalization of CdtB and subsequent translocation into the nucleus of target cells results in DNA-strand breaks, leading to cell-cycle arrest and apoptosis. CdtB crystals were grown using microbatch methods with polyethylene glycol 8000 as the precipitant. The CdtB crystals contain one molecule of MW 30. ...[more]