Ontology highlight
ABSTRACT:
SUBMITTER: Serre D
PROVIDER: S-EPMC2198793 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Serre David D Montpetit Alexandre A Paré Guillaume G Engert James C JC Yusuf Salim S Keavney Bernard B Hudson Thomas J TJ Anand Sonia S
PloS one 20080102 1
<h4>Background</h4>The vast majority of genetic risk factors for complex diseases have, taken individually, a small effect on the end phenotype. Population-based association studies therefore need very large sample sizes to detect significant differences between affected and non-affected individuals. Including thousands of affected individuals in a study requires recruitment in numerous centers, possibly from different geographic regions. Unfortunately such a recruitment strategy is likely to co ...[more]