Ontology highlight
ABSTRACT:
SUBMITTER: Degli-Esposti MA
PROVIDER: S-EPMC2199077 | biostudies-literature | 1997 Oct
REPOSITORIES: biostudies-literature
Degli-Esposti M A MA Smolak P J PJ Walczak H H Waugh J J Huang C P CP DuBose R F RF Goodwin R G RG Smith C A CA
The Journal of experimental medicine 19971001 7
TRAIL-R3, a new member of the TRAIL receptor family, has been cloned and characterized. TRAIL-R3 encodes a 299 amino acid protein with 58 and 54% overall identity to TRAIL-R1 and -R2, respectively. Transient expression and quantitative binding studies show TRAIL-R3 to be a plasma membrane-bound protein capable of high affinity interaction with the TRAIL ligand. The TRAIL-R3 gene maps to human chromosome 8p22-21, clustered with the genes encoding two other TRAIL receptors. In contrast to TRAIL-R1 ...[more]