Ontology highlight
ABSTRACT:
SUBMITTER: Degani S
PROVIDER: S-EPMC2199222 | biostudies-literature | 2002 Jan
REPOSITORIES: biostudies-literature
Degani Simona S Balzac Fiorella F Brancaccio Mara M Guazzone Simona S Retta Saverio Francesco SF Silengo Lorenzo L Eva Alessandra A Tarone Guido G
The Journal of cell biology 20020121 2
Using two-hybrid screening, we isolated the integrin cytoplasmic domain-associated protein (ICAP-1), an interactor for the COOH terminal region of the beta1A integrin cytoplasmic domain. To investigate the role of ICAP-1 in integrin-mediated adhesive function, we expressed the full-length molecule in NIH3T3 cells. ICAP-1 expression strongly prevents NIH3T3 cell spreading on extracellular matrix. This inhibition is transient and can be counteracted by coexpression of a constitutively activated mu ...[more]