Ontology highlight
ABSTRACT:
SUBMITTER: Mouilleron S
PROVIDER: S-EPMC2203311 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Mouilleron Stéphane S Golinelli-Pimpaneau Béatrice B
Protein science : a publication of the Protein Society 20070301 3
Glucosamine-6-phosphate synthase channels ammonia over 18 A from glutamine at the glutaminase site to fructose-6P at the synthase site. We have modeled the anisotropic displacements of the glutaminase and synthase domains from the two crystallized states, the enzyme in complex with fructose-6P or in complex with glucose-6P and a glutamine affinity analog, using TLS (rigid-body motion in terms of translation, libration, and screw motions) refinement implemented in REFMAC. The domains displacement ...[more]