Homers regulate drug-induced neuroplasticity: implications for addiction.
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ABSTRACT:
SUBMITTER: Szumlinski KK
PROVIDER: S-EPMC2204062 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
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Homers regulate drug-induced neuroplasticity: implications for addiction.
Szumlinski Karen K KK Ary Alexis W AW Lominac Kevin D KD
Biochemical pharmacology 20070727 1
Drug addiction is a chronic, relapsing disorder, characterized by an uncontrollable motivation to seek and use drugs. Converging clinical and preclinical observations implicate pathologies within the corticolimbic glutamate system in the genetic predisposition to, and the development of, an addicted phenotype. Such observations pose cellular factors regulating glutamate transmission as likely molecular candidates in the etiology of addiction. Members of the Homer family of proteins regulate sign ...[more]
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