Ontology highlight
ABSTRACT:
SUBMITTER: Mortl M
PROVIDER: S-EPMC2204121 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Mörtl Mario M Sonderegger Peter P Diederichs Kay K Welte Wolfram W
Protein science : a publication of the Protein Society 20070831 10
Human TAG-1 is a neural cell adhesion molecule that is crucial for the development of the nervous system during embryogenesis. It consists of six immunoglobulin-like and four fibronectin III-like domains and is anchored to the membrane by glycosylphosphatidylinositol. Herein we present the crystal structure of the four N-terminal immunoglobulin-like domains of TAG-1 (TAG-1(Ig1-4)), known to be important in heterophilic and homophilic macromolecular interactions. The contacts of neighboring molec ...[more]