Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Rodriguez C
PROVIDER: S-EPMC22056 | biostudies-literature | 1999 Jun
REPOSITORIES: biostudies-literature
Lopez-Rodríguez C C Aramburu J J Rakeman A S AS Rao A A
Proceedings of the National Academy of Sciences of the United States of America 19990601 13
NFAT transcription factors are related to NF-kappaB/Rel proteins and form cooperative complexes with Fos and Jun on DNA. We have identified an NFAT-related protein, NFAT5, which differs from the conventional NFAT proteins NFAT1-4 in its structure, DNA binding, and regulation. NFAT5 contains a NFAT-like Rel homology domain, conserves the DNA contact residues of NFAT1-4, and binds DNA sequences similar to those found in the regulatory regions of well-characterized NFAT-dependent genes. However, it ...[more]