Ontology highlight
ABSTRACT:
SUBMITTER: Kumari S
PROVIDER: S-EPMC2206252 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Kumari Sunita S Bugaut Anthony A Huppert Julian L JL Balasubramanian Shankar S
Nature chemical biology 20070225 4
Guanine-rich nucleic acid sequences can adopt noncanonical four-stranded secondary structures called guanine (G)-quadruplexes. Bioinformatics analysis suggests that G-quadruplex motifs are prevalent in genomes, which raises the need to elucidate their function. There is now evidence for the existence of DNA G-quadruplexes at telomeres with associated biological function. A recent hypothesis supports the notion that gene promoter elements contain DNA G-quadruplex motifs that control gene expressi ...[more]