The A2b adenosine receptor protects against vascular injury.
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ABSTRACT:
SUBMITTER: Yang D
PROVIDER: S-EPMC2206615 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Publications
The A2b adenosine receptor protects against vascular injury.
Yang Dan D Koupenova Milka M McCrann Donald J DJ Kopeikina Katherine J KJ Kagan Herbert M HM Schreiber Barbara M BM Ravid Katya K
Proceedings of the National Academy of Sciences of the United States of America 20080109 2
The A2b adenosine receptor (A2bAR) is highly abundant in bone marrow macrophages and vascular smooth muscle cells (VSMC). To examine the functional significance of this receptor expression, we applied a femoral artery injury model to A2bAR knockout (KO) mice and showed that the A2bAR prevents vascular lesion formation in an injury model that resembles human restenosis after angioplasty. While considering related mechanisms, we noted higher levels of TNF-alpha, an up-regulator of CXCR4, and of VS ...[more]
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