Ontology highlight
ABSTRACT:
SUBMITTER: Mihajlovic M
PROVIDER: S-EPMC2206986 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Mihajlovic Maja M Lazaridis Themis T
Protein science : a publication of the Protein Society 20070727 9
Intestinal fatty acid binding protein (IFABP) interacts with biological membranes and delivers fatty acid (FA) into them via a collisional mechanism. However, the membrane-bound structure of the protein and the pathway of FA transfer are not precisely known. We used molecular dynamics (MD) simulations with an implicit membrane model to determine the optimal orientation of apo- and holo-IFABP (bound with palmitate) on an anionic membrane. In this orientation, the helical portal region, delimited ...[more]