Scaffolding proteins in G-protein signaling.
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ABSTRACT:
SUBMITTER: Andreeva AV
PROVIDER: S-EPMC2211295 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Publications
Scaffolding proteins in G-protein signaling.
Andreeva Alexandra V AV Kutuzov Mikhail A MA Voyno-Yasenetskaya Tatyana A TA
Journal of molecular signaling 20071030
Heterotrimeric G proteins are ubiquitous signaling partners of seven transmembrane-domain G-protein-coupled receptors (GPCRs), the largest (and most important pharmacologically) receptor family in mammals. A number of scaffolding proteins have been identified that regulate various facets of GPCR signaling. In this review, we summarize current knowledge concerning those scaffolding proteins that are known to directly bind heterotrimeric G proteins, and discuss the composition of the protein compl ...[more]
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