Ontology highlight
ABSTRACT:
SUBMITTER: Nauli S
PROVIDER: S-EPMC2211692 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20071101 11
Obtaining well-diffracting crystals of macromolecules remains a significant barrier to structure determination. Here we propose and test a new approach to crystallization, in which the crystallization target is fused to a polymerizing protein module, so that polymer formation drives crystallization of the target. We test the approach using a polymerization module called 2TEL, which consists of two tandem sterile alpha motif (SAM) domains from the protein translocation Ets leukemia (TEL). The 2TE ...[more]