Ontology highlight
ABSTRACT:
SUBMITTER: Vance RE
PROVIDER: S-EPMC2212405 | biostudies-literature | 1998 Nov
REPOSITORIES: biostudies-literature
Vance R E RE Kraft J R JR Altman J D JD Jensen P E PE Raulet D H DH
The Journal of experimental medicine 19981101 10
Natural killer (NK) cells preferentially lyse targets that express reduced levels of major histocompatibility complex (MHC) class I proteins. To date, the only known mouse NK receptors for MHC class I belong to the Ly49 family of C-type lectin homodimers. Here, we report the cloning of mouse NKG2A, and demonstrate it forms an additional and distinct class I receptor, a CD94/NKG2A heterodimer. Using soluble tetramers of the nonclassical class I molecule Qa-1(b), we provide direct evidence that CD ...[more]